Лекции на Prof. M. Moloney

Колеги,

от 24 септември до 27 септември 2012 година
в Химическия факултет гостува
Prof. Mark Moloney – University of Oxford
който ще изнесе цикъл лекции
„Advanced Organic Chemistry- Stereoselective Synthesis“
както следва:

Lecture 1 – Stereochemistry: review of stereochemical definitions; stereochemical processes and tereoselectivity.

Lecture 2 – Determination of optical activity, and problems and difficulties with [ ]D; enantiomeric excess determination by chiral derivatisation, chromatography and chiral shift n.m.r. spectroscopy.  The chiral pool.

Lecture 3 – Stereoselective bond formation using chiral starting materials.  Reactions which do not disrupt existing chirality. Use of chiral auxiliaries: alkylation of ketones (Ender’s method, alkylation of chiral enamines); alkylation of carboxylic acids (methods of Meyers, Evans, Davies, and Schollkopf, and alkylation of glycine imines).

Lecture 4 – Stereoselective bond formation using chiral reagents. Use of stoichiometric reagents for asymmetric synthesis: asymmetric hydride reductions, hydroborations and deprotonations;  chiral allylboranes for carbon-carbon bond formation.

Lecture 5 – Stereoselective bond formation using chiral catalysts. Asymmetric oxidation, epoxidation (Sharpless and Jacobsen); asymmetric dihydroxylation and aminohydroxylation (Sharpless); catalytic asymmetric hydrogenation; asymmetric hydride reduction (CBS).  cyclopropanations; nucleophilic additions; Diels-Alder reactions;  palladium-catalysed allylic alkylations.

Начало на лекциите 10:30 часа във 2 компютърна зала на Химическия факултет.

Канят се всички студенти и преподаватели.