Staff:
1. Assoc. Prof. Stela Mironova Statkova-Abeghe, PhD – Head of Department
2. Prof. Iliyan Ivanov Ivanov, PhD
3. Assoc. Prof. Stoyanka Nikolova Atanasova, PhD
4. Assoc. Prof. Rumiana Ivanova Bakalska, PhD
5. Assoc. Prof. Plamen Angelov Angelov, PhD
6. Assoc. Prof. Dimitar Georgiev Bojilov, PhD
7. Assist. Prof. Stanimir Petrov Manolov, PhD
8. Assist. Prof. Jordan Ivanov Stremski, PhD
9. Assist. Prof. Mina Mihailova Todorova, PhD
10. Katia Dimitrova Stancheva
11.  Sezan Salim Ahmed, MSc

• Synthesis of biologically active organic compounds.
  The investigations of research group include the preparation of new organic compounds with potential biological activity. The investigations for the last several years included the application of the intra- and intermolecular alfa-amidoalkylation reaction for the synthesis of variety of isoquinoline derivarives and some other N-heterocyclic compounds, including alkaloids. We also investigate the application of ortho-substituted amines in the synthesis of N-heterocycles and construction of isoquinoline, beta-carboline and quinazolinone skeleton in the presence of polyphosphoric acid, which is a permanent interest in synthetic application for us. This approach provides an alternative, convenient route to the isoquinoline ring formation.
  Team:
  Prof. I. Ivanov, PhD
  Assoc.Prof. St. Statkova-Abeghe, PhD
  Assoc.Prof. St. Atanasova, PhD
  Assoc. Prof. P. Angelov, PhD
  Assist. Prof. S. Manolov, PhD
  Assist. Prof. J. Stremski, PhD
  Selected Publications:
  1. Venkov A., and Angelov P. “Synthesis of Unsymmetrical beta-Enamino Ketones” Synthesis, 2003, 14, 2221.
  2. Angelov P., Ivanov I., and Venkov A. “Synthesis of Some Novel 11b-Substituted Pyrimido[6,1-a]-isoquinoline Derivatives”, Molecules, 2004, 9, 694.
  3. Venkov A., Statkova-Abeghe S., Donova A., Amidoalkylation of Heteroaromatic Compounds with Adducts of Acyl Chlorides and 3,4-Dihydroisoquinoline and Isoquinoline” Central Eur. J Sci., 2004, 2, 234.
  4. Ivanov, I., Nikolova, S., Statkova-Abeghe S. “A simple method for the synthesis of 1-substituted beta-carboline derivatives from tryptamine and carboxylic acids in polyphosphoric acid”, Heterocycles, 2005, 65, 2483.
  5. Ivanov, I., Nikolova, S., Statkova-Abeghe, S., Angelov P. “A synthesis of N-formylenamides of isoquinoline”, Heterocycles, 2006, 68, 387.
  6. Ivanov, I., Nikolova, S., Kochovska, E., Statkova-Abeghe, S. “Polyphosphoric acid-induced construction of quinazolinone skeleton from 1-(3,4-dimethoxyphenyl)-3-phenylurea and carboxylic acids”, Heterocycles, 2006, 68, 1443.

• Syntheses, spectral and structural investigation of codeine and its derivatives.
  As a part of the research work of the department are transformations (chemical, photochemical, MW) of morphine alkaloids, as well as structural and spectral investigation.
  Team:
  Assoc. Prof. R. Bakalska, PhD
  Assist. Prof. M. Todorova, PhD
  Selected publications:
  1. Bakalska, R., B. Ivanova, T. Kolev: “Linear-dichroic infrared spectral (IR-LD) analysis of codeine and N-norcodeine derivatives”, Central Eur. J. Chem., 4(3) (2006), 533-542.
  2. Kolev, T., R. Bakalska, B. Shivachev, R. Petrova: “Codeinone”, Acta Cryst. E62 (2006), o255-o257.
  3. Kolev, T., R. Bakalska, B. Shivachev, R. Petrova: “6-acetylcodeine”, Acta Cryst. E61 (2005), o2582-o2584.
  4. Kolev, T., B. B. Ivanova, R. Bakalska: “6-O-Acetylcodeine and its hydrogen-squarate – linear-dichroic infrared (IR-LD) spectroscopy”, J. Mol. Struct., 794 (2006), 138-141.
  5. Bakalska, R., Chervenkova, V. B.: “Direct oxidation of codeine to codeinone”, Bulg. Chem. Ind. 73 (3-4), (2002), 108-111.