{"id":2134,"date":"2012-09-14T16:20:20","date_gmt":"2012-09-14T13:20:20","guid":{"rendered":"http:\/\/argon.uni-plovdiv.bg\/?p=2134"},"modified":"2012-09-14T16:20:20","modified_gmt":"2012-09-14T13:20:20","slug":"%d0%bb%d0%b5%d0%ba%d1%86%d0%b8%d0%b8-%d0%bd%d0%b0-prof-m-moloney","status":"publish","type":"post","link":"https:\/\/blogs.uni-plovdiv.net\/argon\/?p=2134","title":{"rendered":"\u041b\u0435\u043a\u0446\u0438\u0438 \u043d\u0430 Prof. M. Moloney"},"content":{"rendered":"

\u041a\u043e\u043b\u0435\u0433\u0438,<\/p>\n

\u043e\u0442 24 \u0441\u0435\u043f\u0442\u0435\u043c\u0432\u0440\u0438 \u0434\u043e 27 \u0441\u0435\u043f\u0442\u0435\u043c\u0432\u0440\u0438 2012 \u0433\u043e\u0434\u0438\u043d\u0430
\n\u0432 \u0425\u0438\u043c\u0438\u0447\u0435\u0441\u043a\u0438\u044f \u0444\u0430\u043a\u0443\u043b\u0442\u0435\u0442 \u0433\u043e\u0441\u0442\u0443\u0432\u0430
\nProf. Mark Moloney – University of Oxford<\/strong>
\n\u043a\u043e\u0439\u0442\u043e \u0449\u0435 \u0438\u0437\u043d\u0435\u0441\u0435 \u0446\u0438\u043a\u044a\u043b \u043b\u0435\u043a\u0446\u0438\u0438
\n„Advanced Organic Chemistry- Stereoselective Synthesis“<\/strong><\/em>
\n\u043a\u0430\u043a\u0442\u043e \u0441\u043b\u0435\u0434\u0432\u0430:<\/p>\n

Lecture 1<\/strong> \u2013 Stereochemistry: review of stereochemical definitions; stereochemical processes and tereoselectivity.<\/p>\n

Lecture 2<\/strong> – Determination of optical activity, and problems and difficulties with [ ]D; enantiomeric excess determination by chiral derivatisation, chromatography and chiral shift n.m.r. spectroscopy.\u00a0 The chiral pool.<\/p>\n

Lecture 3<\/strong> \u2013 Stereoselective bond formation using chiral starting materials.\u00a0 Reactions which do not disrupt existing chirality. Use of chiral auxiliaries: alkylation of ketones (Ender’s method, alkylation of chiral enamines); alkylation of carboxylic acids (methods of Meyers, Evans, Davies, and Schollkopf, and alkylation of glycine imines).<\/p>\n

Lecture 4<\/strong> \u2013 Stereoselective bond formation using chiral reagents. Use of stoichiometric reagents for asymmetric synthesis: asymmetric hydride reductions, hydroborations and deprotonations;\u00a0 chiral allylboranes for carbon-carbon bond formation.<\/p>\n

Lecture 5<\/strong> \u2013 Stereoselective bond formation using chiral catalysts. Asymmetric oxidation, epoxidation (Sharpless and Jacobsen); asymmetric dihydroxylation and aminohydroxylation (Sharpless); catalytic asymmetric hydrogenation; asymmetric hydride reduction (CBS).\u00a0 cyclopropanations; nucleophilic additions; Diels-Alder reactions;\u00a0 palladium-catalysed allylic alkylations.<\/p>\n

\u041d\u0430\u0447\u0430\u043b\u043e \u043d\u0430 \u043b\u0435\u043a\u0446\u0438\u0438\u0442\u0435 10:30 \u0447\u0430\u0441\u0430 \u0432\u044a\u0432 2 \u043a\u043e\u043c\u043f\u044e\u0442\u044a\u0440\u043d\u0430 \u0437\u0430\u043b\u0430 \u043d\u0430 \u0425\u0438\u043c\u0438\u0447\u0435\u0441\u043a\u0438\u044f \u0444\u0430\u043a\u0443\u043b\u0442\u0435\u0442.<\/p>\n

\u041a\u0430\u043d\u044f\u0442 \u0441\u0435 \u0432\u0441\u0438\u0447\u043a\u0438 \u0441\u0442\u0443\u0434\u0435\u043d\u0442\u0438 \u0438 \u043f\u0440\u0435\u043f\u043e\u0434\u0430\u0432\u0430\u0442\u0435\u043b\u0438.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u041a\u043e\u043b\u0435\u0433\u0438, \u043e\u0442 24 \u0441\u0435\u043f\u0442\u0435\u043c\u0432\u0440\u0438 \u0434\u043e 27 \u0441\u0435\u043f\u0442\u0435\u043c\u0432\u0440\u0438 2012 \u0433\u043e\u0434\u0438\u043d\u0430 \u0432 \u0425\u0438\u043c\u0438\u0447\u0435\u0441\u043a\u0438\u044f \u0444\u0430\u043a\u0443\u043b\u0442\u0435\u0442 \u0433\u043e\u0441\u0442\u0443\u0432\u0430 Prof. Mark Moloney – University of Oxford \u043a\u043e\u0439\u0442\u043e \u0449\u0435 \u0438\u0437\u043d\u0435\u0441\u0435 \u0446\u0438\u043a\u044a\u043b \u043b\u0435\u043a\u0446\u0438\u0438 „Advanced Organic Chemistry- Stereoselective Synthesis“ \u043a\u0430\u043a\u0442\u043e \u0441\u043b\u0435\u0434\u0432\u0430: Lecture 1 \u2013 Stereochemistry: review of stereochemical definitions; stereochemical processes and tereoselectivity. Lecture 2 – Determination of optical activity, and problems and difficulties […]<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.uni-plovdiv.net\/argon\/index.php?rest_route=\/wp\/v2\/posts\/2134"}],"collection":[{"href":"https:\/\/blogs.uni-plovdiv.net\/argon\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.uni-plovdiv.net\/argon\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.uni-plovdiv.net\/argon\/index.php?rest_route=\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.uni-plovdiv.net\/argon\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2134"}],"version-history":[{"count":2,"href":"https:\/\/blogs.uni-plovdiv.net\/argon\/index.php?rest_route=\/wp\/v2\/posts\/2134\/revisions"}],"predecessor-version":[{"id":2250,"href":"https:\/\/blogs.uni-plovdiv.net\/argon\/index.php?rest_route=\/wp\/v2\/posts\/2134\/revisions\/2250"}],"wp:attachment":[{"href":"https:\/\/blogs.uni-plovdiv.net\/argon\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2134"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.uni-plovdiv.net\/argon\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2134"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.uni-plovdiv.net\/argon\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2134"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}