Колеги,
от 24 септември до 27 септември 2012 година
в Химическия факултет гостува
Prof. Mark Moloney – University of Oxford
който ще изнесе цикъл лекции
“Advanced Organic Chemistry- Stereoselective Synthesis”
както следва:
Lecture 1 – Stereochemistry: review of stereochemical definitions; stereochemical processes and tereoselectivity.
Lecture 2 – Determination of optical activity, and problems and difficulties with [ ]D; enantiomeric excess determination by chiral derivatisation, chromatography and chiral shift n.m.r. spectroscopy. The chiral pool.
Lecture 3 – Stereoselective bond formation using chiral starting materials. Reactions which do not disrupt existing chirality. Use of chiral auxiliaries: alkylation of ketones (Ender’s method, alkylation of chiral enamines); alkylation of carboxylic acids (methods of Meyers, Evans, Davies, and Schollkopf, and alkylation of glycine imines).
Lecture 4 – Stereoselective bond formation using chiral reagents. Use of stoichiometric reagents for asymmetric synthesis: asymmetric hydride reductions, hydroborations and deprotonations; chiral allylboranes for carbon-carbon bond formation.
Lecture 5 – Stereoselective bond formation using chiral catalysts. Asymmetric oxidation, epoxidation (Sharpless and Jacobsen); asymmetric dihydroxylation and aminohydroxylation (Sharpless); catalytic asymmetric hydrogenation; asymmetric hydride reduction (CBS). cyclopropanations; nucleophilic additions; Diels-Alder reactions; palladium-catalysed allylic alkylations.
Начало на лекциите 10:30 часа във 2 компютърна зала на Химическия факултет.
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